That depends on what you're using Milk Thistle for:
A quarterly detox?
Use for 1 week every 3 months
After monthly heartworm preventatives?
Start 2 days before and continue for 2-3 days after treatment.
After prescribed medications?
Start 2 days before and continue use until 2-3 days after the medication is discontinued.
After flea & tick application?
Collar
Use continuously as long as the collar is on.
Oral
Start 2 days before and continue for 2 to 3 days after
Topical
Use for 7 days after the time of application
After vaccinations?
Start 2 days before and continue for 2-3 days after
For allergy sufferers?
Seasonal
Start (with Herbsmith Clear AllerQi & Herbsmith Glimmer) two to three months prior and continue two months after allergy season.
Year-Round
Use Milk Thistle (with Herbsmith Clear AllerQi & Herbsmith Glimmer) daily until allergies are resolved.